Superdrol
By Dr. Alexander Reynolds, MD, CSCS – Sports Medicine Specialist & Performance Consultant
Superdrol (chemical name: methasterone), a synthetic anabolic-androgenic steroid (AAS) that emerged in the early 2000s. While I do not advocate or prescribe the use of anabolic steroids—especially those not approved for human use by regulatory bodies such as the FDA—my duty as a physician is to provide accurate, science-based information so athletes can make informed decisions and minimize harm.
This article will provide a comprehensive, evidence-based overview of Superdrol, including its history, mechanisms, benefits, risks, cycle protocols, nutritional considerations, and clinical implications. My goal is not to endorse its use, but to equip professional bodybuilders with the knowledge necessary to understand the compound they may encounter in the underground market or hear about in the gym.
1. Historical Background of Superdrol
Superdrol, or methasterone (17α-methyl-drostanolone), was first synthesized in the 1950s by Syntex Pharmaceuticals but remained largely unused due to concerns about hepatotoxicity. It resurfaced in 2005 when it was introduced as a “prohormone” or “designer steroid” under the brand name Superdrol by Designer Supplements, a company that marketed it as a legal alternative to anabolic steroids.
At the time, Superdrol bypassed legal restrictions because it was not explicitly listed as a controlled substance. Its potency, however, quickly drew attention. Within months, it became a favorite among competitive bodybuilders and powerlifters for its ability to deliver rapid muscle gains and dramatic fat loss—effects typically associated with potent anabolic steroids.
By 2006, the U.S. Drug Enforcement Administration (DEA) classified Superdrol as a Schedule III controlled substance under the Anabolic Steroids Control Act, making it illegal to possess or distribute without a prescription. Despite this, it remains available through underground labs and black-market suppliers, often misrepresented or adulterated.
From a medical standpoint, Superdrol has never been approved for human therapeutic use. There are no long-term clinical trials, no established safety profile, and minimal pharmacokinetic data. What we know comes from case reports, anecdotal evidence, and its structural similarity to other methylated steroids.
2. Positive Effects on the Body
Superdrol is renowned for its powerful anabolic effects, particularly in the context of bodybuilding. Key benefits reported by users—though not clinically validated—include:
Rapid Lean Mass Gains: Superdrol promotes significant nitrogen retention and protein synthesis, leading to noticeable muscle growth within 2–4 weeks. Gains of 8–12 lbs of lean mass in a 6-week cycle are commonly reported, though much of this may be water retention and glycogen storage initially.
Enhanced Strength: Users frequently report dramatic increases in strength, often within the first week. This is likely due to increased phosphocreatine synthesis and improved neuromuscular efficiency.
Fat Loss and Hardening Effect: Superdrol has a unique ability to reduce subcutaneous water retention while promoting intramuscular fullness, giving muscles a “dry,” hard, and vascular appearance—highly desirable in bodybuilding competition.
No Estrogenic Activity: Unlike testosterone or Dianabol, Superdrol does not aromatize into estrogen. This means users avoid gynecomastia, water bloat, and high blood pressure related to estrogenic effects.
High Androgen Receptor Binding Affinity: Superdrol binds strongly to the androgen receptor, making it highly effective even at low doses. Its anabolic-to-androgenic ratio is estimated to be around 600:20, indicating strong muscle-building effects with relatively low androgenic side effects (though this is misleading in practice due to its toxicity).
3. Negative Side Effects and Health Risks
Despite its performance benefits, Superdrol carries significant health risks—many of which are underappreciated by users. As a physician, I must emphasize that Superdrol is one of the most hepatotoxic oral steroids ever marketed.
Hepatotoxicity (Liver Damage):
Superdrol is a 17α-alkylated steroid, meaning it is modified to survive first-pass metabolism in the liver. This modification, however, makes it extremely toxic to hepatic tissue. Studies and clinical reports show that even short-term use (4–6 weeks) can cause:
Elevated liver enzymes (ALT, AST, ALP)
Cholestatic hepatitis
Jaundice (yellowing of skin/eyes)
Liver fibrosis or, in rare cases, acute liver failure
Cardiovascular Risks:
Superdrol negatively impacts lipid profiles:
Decreases HDL (“good” cholesterol) by 50–70%
Increases LDL (“bad” cholesterol)
Promotes endothelial dysfunction and arterial stiffness
These changes increase the risk of atherosclerosis, hypertension, and cardiovascular events—especially concerning in athletes who may already have elevated blood pressure due to intense training.
Endocrine Suppression:
Superdrol strongly suppresses the hypothalamic-pituitary-testicular axis (HPTA). Even a 4-week cycle can shut down natural testosterone production for weeks to months. Post-cycle therapy (PCT) is essential, but recovery is often incomplete without medical intervention.
Other Side Effects:
Hair Loss: Accelerates androgenic alopecia in genetically predisposed individuals.
Acne and Oily Skin: Due to increased sebum production.
Insulin Resistance: May impair glucose uptake, increasing diabetes risk.
Joint Pain and Dryness: Many users report joint discomfort, likely due to reduced systemic water retention and suppressed natural hormone production.
Aggression and Mood Swings: Though not estrogenic, Superdrol can affect neurosteroid pathways, leading to irritability or anxiety (“roid rage”).
4. Why Is Superdrol Sought After by Bodybuilders?
Despite its risks, Superdrol remains popular in the bodybuilding community for several reasons:
Speed of Results: In a sport where appearance is judged on a specific date, rapid transformation is invaluable. Superdrol delivers visible changes in muscle hardness and vascularity faster than most compounds.
Lean Gains Without Bloat: Unlike testosterone or Dianabol, Superdrol doesn’t cause estrogenic water retention. This makes it ideal for pre-contest phases when dryness and definition are critical.
No Need for Ancillaries: Because it doesn’t convert to estrogen, users avoid the need for aromatase inhibitors (AIs) or SERMs during the cycle—though PCT is still required.
Perceived “Controlled” Use: Many believe that short cycles (4–6 weeks) with liver support supplements make Superdrol “safe.” This is a dangerous misconception. Hepatotoxicity can occur even at low doses and in healthy individuals.
Legacy and Reputation: Superdrol has a mythos in bodybuilding circles. Older pros speak of its power, and younger athletes seek it out as a “rite of passage” or secret weapon.
5. Proper Usage and Dosing
If a patient insists on using Superdrol despite medical advice, I stress the following harm-reduction principles:
Cycle Length: Never exceed 4–6 weeks. Liver damage risk increases exponentially beyond this.
Dosage: 10–20 mg per day is sufficient. Higher doses (30–40 mg) do not increase gains proportionally but drastically increase toxicity.
Timing: Best used in a cutting or pre-contest phase when lean mass gains and fat loss are prioritized.
Liver Monitoring: Mandatory blood work before, during (at 3 weeks), and after the cycle. Key markers: ALT, AST, GGT, ALP, bilirubin, and albumin.
Liver Support: Use evidence-based supplements such as:
N-acetylcysteine (NAC) – 1200 mg/day
TUDCA (Tauroursodeoxycholic acid) – 500–1000 mg/day
Milk thistle (standardized to 80% silymarin) – 300 mg 2–3x/day
Avoid unproven “liver detox” products.
6. Bodybuilding Cycles: Stacking and Timing
Superdrol is rarely used alone. It is typically part of a stack designed for maximum hardness and definition.
Example 1: Pre-Contest Cutting Stack (8–12 weeks)
Weeks 1–6: Superdrol 15 mg/day
Weeks 1–12: Testosterone Propionate 50 mg every other day (to maintain baseline hormone levels)
Weeks 1–12: Trenbolone Acetate 50 mg every other day (advanced users only)
Weeks 4–12: Anavar 20–40 mg/day (for additional fat loss and vascularity)
AIs: Not needed due to lack of aromatization
Example 2: Standalone Superdrol Cycle (For Beginners)
Weeks 1–6: Superdrol 10–15 mg/day
Support: NAC, TUDCA, CoQ10, Omega-3s
PCT: Begin 3 days after last dose
Clomid 50 mg/day for 2 weeks, then 25 mg/day for 2 weeks
HCG (optional): 500 IU every 3rd day for 2 weeks prior to PCT
Important Notes:
Do not stack Superdrol with other 17α-alkylated orals (e.g., Anadrol, Dianabol, Winstrol) — this multiplies liver risk.
Avoid combining with high-dose trenbolone—both are harsh on lipids and can cause severe cardiovascular strain.
Never use Superdrol in a “bridge” or off-season cycle. Its place is strictly in cutting phases.
7. Nutrition While Using Superdrol
Nutrition is critical during a Superdrol cycle to maximize gains and support organ health.
Caloric Intake:
In a cutting phase: Maintain a moderate deficit (15–20% below maintenance).
Avoid extreme deficits, which can exacerbate joint pain and muscle loss.
Macronutrient Breakdown:
Protein: 1.2–1.5 g per pound of body weight (2.6–3.3 g/kg) to support nitrogen retention.
Fats: 0.5–0.7 g per pound—focus on omega-3s (fatty fish, flaxseed, walnuts) to counteract lipid damage.
Carbohydrates: Adjust based on training intensity. Prioritize complex carbs (oats, sweet potatoes) to fuel workouts and replenish glycogen.
Key Nutritional Support:
Antioxidants: Vitamin C (1000 mg/day), Vitamin E (400 IU), selenium—help combat oxidative stress from liver metabolism.
Electrolytes: Superdrol can cause cramping due to intracellular water shifts. Ensure adequate sodium, potassium, and magnesium.
Hydration: Drink 1–1.5 gallons of water daily to support liver and kidney function.
Avoid Alcohol: Absolutely contraindicated. Alcohol multiplies liver toxicity.
8. Post-Cycle Therapy (PCT) and Recovery
PCT is non-negotiable. Superdrol suppresses natural testosterone production aggressively.
Recommended PCT Protocol:
Start 3–5 days after last Superdrol dose.
HCG (optional): 500–750 IU every 3rd day for 10–15 days to “jumpstart” testes.
Clomiphene Citrate (Clomid): 50 mg/day for 2 weeks, then 25 mg/day for 2 weeks.
Tamoxifen (Nolvadex): 20 mg/day for 4 weeks (alternative or adjunct to Clomid).
Monitor blood work at 4 and 8 weeks post-cycle: Total testosterone, LH, FSH, lipids, liver enzymes.
Recovery can take 4–12 weeks. Some users experience prolonged low energy, libido, and mood changes—indicative of incomplete HPTA recovery.
9. Final Medical and Ethical Considerations
As a physician, I must reiterate: Superdrol is not safe. It is an unapproved, hepatotoxic compound with no therapeutic benefit that outweighs its risks. Its use violates anti-doping regulations (WADA, IFBB, etc.) and may result in disqualification, fines, or long-term health consequences.
That said, I recognize that some professional bodybuilders will use it. My role is not to judge, but to minimize harm. If you choose to use Superdrol:
Get baseline and follow-up blood work.
Limit cycles to 4–6 weeks.
Use liver support aggressively.
Plan PCT in advance.
Never combine with other hepatotoxic agents.
Listen to your body—jaundice, dark urine, or abdominal pain mean STOP IMMEDIATELY.
Conclusion
Superdrol remains one of the most potent—and dangerous—oral compounds in bodybuilding history. Its ability to deliver rapid, dry muscle gains makes it a tempting tool for athletes under competitive pressure. However, its extreme liver toxicity, lipid damage, and endocrine disruption pose serious long-term health risks.